De novo design of conformationally flexible transmembrane peptides driving membrane fusion

De novo design of potent antimicrobial peptides.

Lipopolysaccharide (LPS), shed by gram-negative bacteria during infection and antimicrobial therapy, may lead to lethal endotoxic shock syndrome. A rational design strategy based on the presumed mechanism of antibacterial effect was adopted to design cationic antimicrobial peptides capable of binding to LPS through tandemly repeated sequences of alternating cationic and nonpolar residues. The p...

De-Novo Design of Antimicrobial Peptides for Plant Protection

This work describes the de-novo design of peptides that inhibit a broad range of plant pathogens. Four structurally different groups of peptides were developed that differ in size and position of their charged and hydrophobic clusters and were assayed for their ability to inhibit bacterial growth and fungal spore germination. Several peptides are highly active at concentrations between 0,1 and ...

Towards Rational de novo Design of Peptides for Inorganic Interfaces

Protein adsorption at inorganic surfaces is highly relevant to nanoand bionanotechnology. Just two examples of great significance are the use of specific peptide sequences to control cell deposition on tissue scaffolds, and the tethering of bio-photosynthetic reaction centers on electrodes to harvest light for power generation and hydrogen production. Understanding of the behavior of proteins i...

Running Head: De Novo Design of Β-hairpin Antimicrobial Peptides

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers.

The emergence of drug-resistant bacteria has compromised the use of many conventional antibiotics, leading to heightened interest in a variety of antimicrobial peptides. Although these peptides have attractive potential as antibiotics, their size, stability, tissue distribution, and toxicity have hampered attempts to harness these capabilities. To address such issues, we have developed small (m...